Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks

Javed Khan1,2, Jun S. Wei1, Markus Ringnér1,3, Lao H. Saal1, Marc Ladanyi4, Frank Westermann5 , Frank Berthold6, Manfred Schwab5, Cristina R. Antonescu4, Carsten Peterson3, and Paul S. Meltzer1


  1. Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
  2. Pediatric Oncology Branch, Advanced Technology Center, National Cancer Institute,Gaithersburg, Maryland, USA
  3. Complex Systems Division, Department of Theoretical Physics, Lund University, Lund, Sweden
  4. Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
  5. Department of Cytogenetics, German Cancer Research Center, Heidelberg, Germany
  6. Department of Pediatrics, Klinik für Kinderheilkunde der Universität zu Köln, Köln, Germany

    J.K., J.S.W. and M.R. contributed equally to this study.

    Correspondence should be addressed to J.K. or P.S.M.; email: khanjav@mail.nih.gov or pmeltzer@nhgri.nih.gov


NATURE MEDICINE · VOLUME 7 · NUMBER 6 · JUNE 2001


Supplemental information:

  1. Supplemental Data: List of 2308 genes included in data analysis after filtering. Download tab-delimited text file

  2. Supplemental Table A: The results of ANN calibration for training samples. Download PDF file

  3. Supplemental Table B: Known molecular characteristics of all samples. Download PDF file

  4. Supplemental Methods. Download PDF file


Supplementary information for Javed Khan, et. al, Nature Medicine, 7(6):673-679, 2001.


The Nature Medicine paper: Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks is available here.

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