Table 2d. A list of all significantly changed genes in ZR-75-1-wt.              
         
CloneID Cal. Ratio Cell Line Int. Refer. Int. Description  
198205 5.713 13414.5 852.3 B-myb  
49950 4.909 23474.0 1735.6 rad2 = Homologue of yeast DNA repair gene    
48398 4.272 19902.7 1690.9 cdc25B  
34647 3.768 24402.5 2350.7 Human mRNA for Nm23 protein, involved in developmental regulation (ho    
48085 3.740 18699.0 1814.7 H. sapiens ERF-1 mRNA 5' end    
248032 3.402 3492.2 372.6 Topoisomerase II    
28116 3.312 13418.5 1470.4 Human Rch1 (RCH1) mRNA, complete cds    
39903 3.190 14364.5 1634.5 Human (HepG2) glucose transporter gene mRNA, complete cds    
267682 2.984 9165.6 1114.8 hPAK65 =  serine kinase homologue of rat PAK65    
243159 2.895 17962.9 2252.4 NAIP  
366647 2.707 15695.6 2104.4 ERF-1 = BERG36    
37366 2.673 47117.3 6396.8 Human mRNA fragment encoding beta-tubulin. (from clone D-beta-1)    
40874 2.666 37706.3 5133.3 Human gamma-tubulin mRNA, complete cds    
51018 0.379 4156.8 3976.0 Human lipocortin II mRNA, complete cds    
39159 0.376 4586.8 4424.2 Homo sapiens phosphoglycerate mutase (PGAM-B) mRNA, complete cds    
30573 0.374 1273.1 1236.7 Homo sapiens galactocerebrosidase (GALC) gene    
417592 0.374 1012.5 981.8 MRP = MDR-associated protein    
50203 0.373 3392.9 3304.6 Human mRNA for calretinin    
30149 0.370 13763.3 13491.4 Human mRNA for liver-type alkaline phosphatase (EC 3.1.3.1)    
427857 0.367 3211.3 3177.8 Cyclin A  
24392 0.363 7261.3 7254.5 Human HLA-B-associated transcript 3 (BAT3) gene, 5' end    
26789 0.363 8641.3 8637.5 Human laminin B2 chain mRNA, complete cds    
469272 0.363 1987.1 1987.2 EGF Receptor    
306013 0.362 6378.2 6401.4 CD20 p35 subunit = B1    
23731 0.358 2065.2 2091.0 Human peptidylglycine alpha-amidating monooxygenase mRNA, complete cds    
328692 0.358 3401.4 3452.8 IL-8  
376218 0.356 1921.3 1960.3 Probable transcription factor PML {alternative products}    
38647 0.353 8882.4 9142.1 Human placental calpastatin mRNA, partial cds    
114648 0.352 1470.3 1514.1 NFkB1 = NF-kappaB p105    
323776 0.352 5586.4 5760.1 bFGF  = basic FGF = FGF-2    
24638 0.350 3530.6 3664.3 Human ras-related protein (Krev-1) mRNA, complete cds    
362926 0.350 2624.1 2717.4 PKA-C beta = protein kinase A catalytic subunit, beta isoform    
24642 0.349 5656.0 5877.2 Human phosphodiesterase I alpha mRNA    
268652 0.349 1497.8 1558.7 p21 cyclin kinase inhibitor    
380403 0.348 13855.5 14449.2 rhoA  
25764 0.347 5502.5 5752.6 Human angiotensinogen (AGT) gene    
50363 0.346 7921.4 8305.0 Human nonerythroid alpha-spectrin (SPTAN1) mRNA, complete cds    
37485 0.345 2092.7 2202.0 Human mRNA for carboxypeptidase E (EC 3.4.17.10)    
40205 0.342 5214.6 5532.2 Human cathepsin B proteinase mRNA, complete cds    
49584 0.340 1245.4 1331.0 H.sapiens (HepG2) LAL mRNA for lysosomal acid lipase    
201673 0.340 1201.4 1283.0 IRF-2  
415102 0.336 3503.7 3789.4 cdc25Hs = cdc25c = M-PHASE INDUCER PHOSPHATASE 3    
26286 0.333 4024.5 4380.1 Human macrophage mannose receptor (MRC1) gene    
306134 0.333 949.2 1035.0 KKIALRE = novel cdk    
24886 0.332 2055.2 2243.7 Human mRNA for MTG8 protein, complete cds    
41356 0.331 6078.8 6656.7 Homo sapiens protein phosphatase 2A B56-alpha mRNA, complete cds    
43858 0.331 2413.8 2649.2 H.sapiens mRNA for receptor protein tyrosine kinase    
26052 0.326 15896.0 17673.1 Human glutathione S-transferase mRNA, complete cds    
138998 0.325 1003.6 1121.2 Homologue of seven in absentia    
512429 0.323 50587.2 56905.2 IGFBP-2  
193901 0.321 1664.4 1880.8 Cell cycle, G1 phase defect, (transcription factor TFIID p250 polypeptide)    
52415 0.320 1030.2 1167.6 Human gene for C1-inhibitor    
44050 0.317 4933.7 5642.9 H.sapiens MLN50 mRNA    
44584 0.317 5738.0 6568.1 Human RIG mRNA, complete sequence    
33183 0.316 14358.0 16490.9 Human mRNA for ribophorin II    
110022 0.315 1598.9 1839.7 Cyclin D1 = BCL1 = PRAD1    
345928 0.315 1803.1 2077.5 Smad1= Sma and Mad homologue    
259291 0.314 5367.5 6200.5 INTEGRIN BETA-5    
271478 0.314 1773.3 2049.9 MXI-1  
31242 0.311 2024.3 2363.8 Human mRNA for protein phosphatase 2A (beta-type)    
470792 0.310 1896.7 2219.7 TRANSCRIPTION INITIATION FACTOR IIB    
40764 0.309 9911.4 11661.1 Human AD amyloid mRNA, complete cds    
124086 0.309 1420.5 1666.6 IL-11 Receptor    
47306 0.308 3306.9 3895.7 Human mRNA for protein kinase C delta-type    
266486 0.304 903.2 1077.1 cdk2  
347573 0.303 2027.0 2426.9 Transcription factor COUP 2 (a.k.a. ARP1)    
33943 0.301 2506.0 3021.1 Human beta-galactosidase (GLB1) mRNA, complete cds    
187987 0.301 1270.5 1531.8 IL-4 receptor alpha chain    
158970 0.300 887.4 1073.6 HEK2  
362009 0.300 2583.3 3129.6 GADD153 =g rowth arrest and DNA-damage-inducible gene    
253773 0.299 1184.6 1436.3 IAP2 = MIHB  
488801 0.296 1354.1 1657.7 HBNF-1  
34327 0.291 36573.8 45604.1 Human cellular oncogene c-fos (complete sequence)    
32750 0.289 6770.7 8508.5 H.sapiens serum paraoxonase (PON) mRNA, complete cds    
199381 0.288 1299.7 1640.0 VAV  
256323 0.287 16658.7 21054.0 SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3    
39169 0.285 17415.8 22160.5 Human 26-kDa cell surface protein TAPA-1 mRNA, complete cds    
50999 0.284 2753.6 3521.7 Human aldehyde dehydrogenase 1 mRNA    
375724 0.284 19540.3 24976.9 CAMP-dependent transcription factor ATF-4 (CREB2)    
361381 0.283 1762.6 2260.8 MCL1  
115336 0.280 2147.3 2782.2 beta-galactoside alpha-2,6-sialyltransferase =  CD75 = CDw75    
50555 0.279 26398.3 34299.3 H.sapiens mRNA for ribosomal protein L3    
162584 0.279 1932.7 2513.2 B-lymphocyte antigen precursor = XE7    
154763 0.277 1438.9 1883.7 Probable transcription factor PML {alternative products}    
39796 0.276 3167.3 4172.2 Human hydroxymethylglutaryl-CoA lyase mRNA, complete cds    
375724 0.276 23368.8 30759.8 ATF-4 = TAXREB67 = CREB2?    
44178 0.272 6166.9 8225.8 H.sapiens TEGT gene    
28774 0.271 1208.4 1616.4 HPTP delta = protein tyrosine phosphatase delta    
343166 0.268 4938.5 6683.2 PSSALRE = cdk5    
34761 0.267 8436.2 11484.1 Human mRNA (KIAA0026) for ORF (complete cds) and HepG2 mRNA identical    
41208 0.267 2145.2 2913.4 Homo sapiens (clone KT2) bone morphogenetic protein-1 (BMP-1) mRNA and alternatively spliced mammal  
31355 0.265 2231.9 3053.1 H.sapiens Id1 mRNA    
158970 0.265 803.6 1099.1 HEK2  
46777 0.264 24885.3 34159.1 Human scar protein mRNA, complete cds    
361815 0.262 2958.1 4100.3 ESTs, Highly  similar to TRANSCRIPTIONAL ACTIVATOR FE65 [Rattus norvegicus]    
26871 0.261 1626.9 2258.4 Fibroblast growth factor receptor 2    
428404 0.261 1135.5 1579.1 PIM  
487417 0.261 2507.0 3488.6 ERK  
418138 0.258 2065.1 2906.6 shp = sh-ptp1 = ptp1c = hcp    
32684 0.257 8971.9 12652.1 Human mRNA for ribosomal protein L32    
25485 0.254 1224.2 1749.5 Homo sapiens neuroendocrine-specific protein A (NSP) mRNA, complete cds    
221619 0.254 891.3 1274.8 MHC Class II = DQ alpha    
49243 0.253 5149.3 7380.2 Human mRNA for Diff6, H5, CDC10 homologue    
509882 0.250 1488.3 2164.2 H.sapiens MTF-1 mRNA for metal-regulatory transcription factor    
484993 0.249 16571.8 24108.3 CD81 ANTIGEN    
487965 0.249 2292.8 3347.3 HHR6A = rad6 homologue    
213502 0.248 2243.9 3289.9 Leukocyte Antigen CD53    
43711 0.246 10435.5 15417.4 Human steroid 5-alpha-reductase mRNA, complete cds    
357909 0.246 1840.5 2718.3 Receptor PTP mu = hR-PTPu    
417218 0.244 1014.8 1511.1 RETINOIC ACID REC RXR-ALPHA    
241489 0.238 11562.6 17608.3 BETA-2 ADRENERGIC RECEPTOR    
41452 0.236 5346.0 8225.4 Spermidine/spermine N1-acetyltransferase mRNA, complete cds    
327396 0.235 6534.1 10079.6 PITSLRE alpha 1    
310141 0.234 1349.4 2089.0 gadd45 (growth arrest &DNA Damage inducible protein)    
37230 0.232 2768.0 4327.3 Human protective protein mRNA, complete cds    
37796 0.232 950.5 1486.1 Human DNA for osteopontin, complete cds    
195889 0.231 1607.3 2529.3 ESTs, Highly  similar to TRANSCRIPTION FACTOR BTF3 [Homo sapiens]    
347751 0.230 877.3 1384.1 FGR  
41094 0.229 3149.6 4998.2 Human tie mRNA for putative receptor tyrosine kinase    
44311 0.229 4006.7 6340.3 H.sapiens MGF gene exons 1&2    
51219 0.229 3350.1 5309.3 Human mRNA for MGC-24, complete cds    
196543 0.223 743.1 1211.1 STAT4  
24652 0.222 1688.8 2761.0 Human CD34 mRNA, complete cds    
380738 0.222 2367.3 3864.8 TRANSCRIPTION FACTOR ITF-2    
417403 0.222 1929.6 3152.9 raf-b = B-raf  
291057 0.215 1341.1 2266.3 p18 (cdk6 inhibitor)    
239287 0.214 609.1 1034.0 CD45  
52162 0.210 4488.2 7744.6 Elongin B = SIII p18 subunit    
34005 0.209 3168.3 5511.8 Human clone pSK1 interferon gamma receptor accessory factor-1 (AF-1)    
51363 0.207 690.2 1211.1 MRC OX-2  
22589 0.205 2174.9 3852.2 Human retinoic acid-inducible E3 protein mRNA, complete cds    
23185 0.204 1315.8 2336.0 Homo sapiens hexabrachion mRNA, complete cds    
41813 0.203 2621.4 4680.3 Human glucose transporter-like protein-III (GLUT3), complete cds    
299539 0.199 2040.0 3722.5 FHF-1 = fibroblast growth factor homologous factor 1    
126519 0.198 836.2 1529.6 ESTs, Moderately  similar to ERYTHROID KRUEPPEL-LIKE TRANSCRIPTION FACTOR [Mus musculus]  
30012 0.197 9498.8 17537.3 H.sapiens mRNA for high endothelial venule    
49691 0.197 1905.9 3515.4 Human prion protein mRNA, human PrP 27-30 mRNA, complete cds    
488092 0.197 1446.9 2670.3 ESTs, Highly  similar to TRANSCRIPTIONAL ACTIVATOR GCN5 [Saccharomyces cerevisiae]    
357357 0.195 1306.2 2435.4 MITOCHONDRIAL TRANSCRIPTION FACTOR 1 PRECURSOR    
366981 0.195 728.0 1352.8 Human transcription factor LSF mRNA, complete cds    
471620 0.194 6174.9 11555.5 CD105 = endoglin    
72869 0.193 682.5 1286.7 beta-NGF  
298187 0.193 1366.6 2571.2 Bcl-xs  
366420 0.191 3425.0 6511.6 MKK6 = mek6    
114116 0.184 5373.8 10594.9 Syndecan-2 = heparin sulfate proteoglycan core protein    
486785 0.184 847.2 1675.4 plasminogen gene    
295389 0.183 564.7 1121.3 GHR Receptor    
36560 0.181 1266.4 2544.9 Human amyloid protein (AD-AP) mRNA, 3' end    
183950 0.181 1399.1 2798.1 Thy-1  
364278 0.181 2310.6 4630.2 c-maf = NRL  
38983 0.180 2191.7 4414.4 Human placental FXIIIa mRNA, complete cds    
359412 0.180 1130.2 2277.0 Cyclin D2  
47884 0.177 593.8 1214.3 Homo sapiens macrophage migration inhibitory factor mRNA, 3' end    
44722 0.175 4212.4 8761.6 H.sapiens mRNA for transcript associated with monocyte to macrophage differentiation    
49164 0.170 741.1 1584.6 CD106 = VCAM-1    
32658 0.169 16310.5 35095.7 Human apolipoprotein J mRNA, complete cds    
470062 0.169 799.5 1720.0 DNA ligase III  
47386 0.167 1564.0 3391.6 Human alpha-1-antichymotrypsin mRNA, 3' end    
22285 0.164 1937.2 4282.1 Human mRNA for erythrocyte band 7 integral membrane protein    
297589 0.160 1104.8 2509.9 AIM1  
357807 0.160 539.1 1225.8 Cyclin E  
77577 0.158 1557.1 3571.3 fra-2  
236420 0.158 615.1 1414.4 receptor protein tyrosine kin    
299198 0.156 521.1 1209.4 CD1E  
34005 0.155 2984.1 7002.9 Interferon gamma receptor beta chain    
53184 0.150 426.4 1034.0 Human transcobalamin II (TCII) mRNA, complete cds    
22012 0.149 2159.6 5273.3 Human ADP-ribosylation factor (ARF3) mRNA, complete cds    
147744 0.148 933.7 2292.8 p57KIP2  
27681 0.147 1187.0 2940.3 Human smooth muscle cell calponin mRNA, complete cds    
310406 0.147 3804.2 9408.2 IL-6  
26593 0.146 2964.3 7348.1 Human complement C1r mRNA, complete cds    
323162 0.146 4081.4 10120.7 cdk3  
262691 0.144 730.8 1838.8 GLUCOCORTICOID RECEPTOR, B    
26572 0.143 4424.0 11268.1 Human myristoylated alanine-rich C-kinase substrate mRNA, complete cds    
489395 0.143 722.3 1835.8 Alpha PDGF Receptor    
50032 0.141 1464.1 3781.2 Human interferon-gamma receptor mRNA, complete cds    
154472 0.141 901.1 2314.2 Fibroblast growth factor receptor 1    
486074 0.140 1057.4 2742.0 MEK1  
49725 0.138 529.2 1392.1 H.sapiens mRNA for neuropeptide Y-like receptor    
22445 0.137 2243.7 5953.2 Human cytochrome b561 gene    
359077 0.137 549.5 1451.3 Fibronectin Recpt Alpha    
51854 0.136 711.4 1892.2 FLI-1 = ERGB  
124927 0.136 1793.6 4802.7 ESTs, Highly  similar to BASIC TRANSCRIPTION FACTOR 62 KD SUBUNIT [Homo sapiens]    
125555 0.133 1082.7 2965.5 ESTs, Highly  similar to CYCLIC-AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-4 [Homo sapiens]  
22379 0.131 4080.6 11273.3 Human lymphocytic antigen CD59/MEM43 mRNA, complete cds    
485690 0.130 9001.3 25130.3 MYOSIN HEAVY CHAIN    
22589 0.128 2095.6 5942.2 Human mRNA (KIAA0085) for ORF (novel protein), partial cds    
360531 0.127 1090.7 3123.8 raf-a = pks = a-raf    
471889 0.126 852.0 2450.4 COUP TRANSCRIPTION FACTOR    
32409 0.124 1708.2 5011.1 Human mRNA (HA1756) for ORF, complete cds    
47679 0.122 1542.1 4597.0 Human monocyte antigen CD14 (CD14) mRNA, complete cds    
86017 0.119 749.1 2291.6 CD54 = ICAM-1    
309477 0.119 8524.8 25978.4 jun-B  
365647 0.117 5293.9 16400.0 CD4  
428248 0.117 1611.4 5004.5 ATF-3 = activating transcription factor 3    
238577 0.115 550.8 1733.3 MHC Class II = DP beta    
343311 0.115 329.2 1035.5 NGF Receptor    
132420 0.114 522.1 1656.3 ets-2  
183661 0.114 484.5 1541.3 T.P.K Receptor  TIE-2    
282065 0.111 679.8 2226.8 ESTs, Highly  similar to TRANSCRIPTIONAL ACTIVATOR FE65 [Rattus norvegicus]    
346396 0.107 562.7 1915.5 R-RAS  
288650 0.104 709.0 2477.7 ESTs, Highly  similar to SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 [Mus musculus]  
376303 0.103 361.9 1275.6 IGF-IA  
510381 0.103 1404.7 4953.3 ESTs, Highly  similar to ERYTHROID KRUEPPEL-LIKE TRANSCRIPTION FACTOR [Mus musculus]    
25400 0.101 2620.9 9381.2 Human transcription factor (ITF-2) mRNA, 3' end