Table 2c. A list of all significantly changed genes in SUM-52.              
         
CloneID Cal. Ratio Cell Line Int. Refer. Int. Description  
272110 17.228 3727.0 57.0 NERF = ets-related factor    
248032 16.384 5211.5 83.8 Topoisomerase II    
126542 12.599 1025.1 21.4 TAK1 = TGF-beta-activated kinase    
293934 8.148 24032.6 776.8 CAS  
281029 7.483 1172.3 41.3 PTP zeta = protein tyrosine phosphatase zeta    
470062 7.124 1163.6 43.0 DNA ligase III  
53227 6.733 11571.0 452.7 Human p18 protein mRNA, complete cds    
284546 6.050 3482.3 151.6 Glial fib Acid Prot    
272110 5.890 5829.9 260.7 Human Ets transcription factor (NERF-2) mRNA, complete cds    
47874 5.540 1706.9 81.2 Human cell adhesion protein (SQM1) mRNA, complete cds    
190711 5.116 1245.8 64.1 EST  
280735 5.111 4320.5 222.6 TRANSCRIPTION INITIATION FACTOR TFIID    
44689 4.765 27662.9 1529.2 Human retinoblastoma-binding protein (RbAp46) mRNA, complete cds    
123953 4.711 5483.9 306.6 MHC Class II = DQ beta    
278409 4.702 1287.4 72.1 MKK4 = MEK-4 = sek1    
359119 4.589 4749.0 272.6 CDK RS2  
243159 4.531 7296.6 424.2 NAIP  
344109 4.407 4459.1 266.5 PCNA  
322029 4.289 5648.6 346.8 JNK2  
357239 4.267 5164.5 318.8 RPA = replication protein A    
366647 4.205 7853.6 492.0 ERF-1 = BERG36    
486012 4.143 3797.2 241.4 RAB-10  
51621 4.077 6213.3 401.4 H.sapiens HLTF-1 gene for helicase-like transcription factor    
34662 4.051 16347.6 1062.8 Homo sapiens signal recognition particle subunit 9 (SRP9) mRNA, compl    
126379 4.037 2921.3 190.6 PTP Psi = receptor protein tyrosine phosphatase psi    
264606 3.986 5830.0 385.2 Homologue of High affinity Fc gamma receptor I - B Form    
298314 3.833 1186.1 81.5 Sp3 = SPR-2  
43229 3.674 13240.9 949.2 Human proliferating cell nuclear antigen (PCNA) gene, complete cds    
129268 3.591 5441.6 399.1 ESTs, Weakly similar to TRANSCRIPTION INITIATION FACTOR IIA SMALL CHAIN [Saccharomyces cerevisiae]  
43885 3.462 12125.7 922.6 Human mRNA for isoleucyl tRNA synthetase  
191007 3.448 5050.0 385.7 RAB-6  
271662 3.422 14829.9 1141.4 CHED = cdc2-related kinase  
42349 3.347 52792.3 4154.0 Human 14-3-3 protein mRNA, complete cds"  
28116 3.336 9174.5 724.3 Human Rch1 (RCH1) mRNA, complete cds    
31863 3.303 25966.3 2070.3 H.sapiens mRNA for novel DNA binding protein    
298371 3.268 1084.0 87.4 HOMEOBOX/POU    
35559 3.262 11220.1 905.9 H.sapiens mitoxantrone-resistance associated mRNA    
123586 3.151 4597.0 384.2 Syndecan-1  
510405 3.109 31600.7 2676.9 CEA  
198205 3.100 1805.2 153.4 B-myb  
415679 2.993 1051.6 92.5 Microtubule Ass Prot 1A    
22568 2.971 4242.3 376.1 H.sapiens ERK3 mRNA    
146307 2.962 1008.3 89.7 VHL TSG  
366824 2.883 6786.6 620.0 cdk4  
40911 2.871 24749.6 2270.2 Human histone (H2A.Z) mRNA, complete cds    
51373 2.843 1243.7 115.2 Human oligodendrocyte-myelin glycoprotein (OMGP) mRNA, complete cds    
221690 2.828 9067.5 844.4 Homologue of RP-8    
50322 2.808 25480.5 2390.2 Human natural killer cell enhancing factor (NKEFA) mRNA, complete cds    
302490 2.804 3711.3 348.6 Cyclin B1  
43601 2.730 1649.3 159.1 Human butyrylcholinesterase (BChEG1) gene    
321308 2.698 1646.0 160.7 Bcl2 p53 bind Prot    
429926 2.685 1043.0 102.3 APC  
115277 2.659 1047.5 103.8 Homologue of TDAG8    
320903 2.646 1013.6 100.9 IL-3 Receptor  
427686 2.635 1923.4 192.3 NF-E2  
42380 2.619 1592.6 160.2 Human mRNA for protein kinase C (PKC) type beta II    
82991 2.618 1833.4 184.5 PC-1 = alkaline nucleotide pyrophosphatase    
38876 2.607 16720.8 1689.5 Homo sapiens (clone hKvBeta3) K+ channel beta subunit mRNA, complete cds    
270980 2.603 1233.6 124.8 FLICE = MACH-alpha-1 = Mch5    
48677 2.598 1337.7 135.6 Human cadherin-associated protein-related (cap-r) mRNA, complete cds    
43622 2.596 1918.5 194.7 Human glutamate receptor 2 (HBGR2) mRNA, complete cds    
37904 2.558 1196.4 123.2 Human protein kinase mRNA, complete cds    
36393 2.549 6951.3 718.2 Human t-complex polypeptide 1 gene    
45658 2.521 2132.3 222.8 Human mRNA for ORF, complete cds    
45604 2.518 2349.7 245.8 H.sapiens mRNA for BCL7A protein    
486335 2.483 4923.5 522.2 ALPHA-ACTININ 1, CYTOSKEL    
487417 2.440 1769.3 191.0 ERK  
48085 2.375 4041.6 448.3 H. sapiens ERF-1 mRNA 5' end    
34647 2.368 3193.8 355.3 Human mRNA for Nm23 protein, involved in developmental regulation (ho    
364716 2.363 2703.7 301.4 GTBP = G/T mismatch binding protein    
43549 2.353 15356.4 1718.6 H.sapiens M gene for M1-type and M2-type pyruvate kinase    
42532 2.349 10290.2 1154.0 Homo sapiens calcium-ATPase (HK2) mRNA, complete cds    
488891 2.328 1170.3 132.4 HHR6B = rad6 homologue    
26541 2.323 3104.9 352.0 Human mitotic feedback control protein Madp2 homolog mRNA, complete cds    
267682 2.322 1656.5 187.9 hPAK65 =  serine kinase homologue of rat PAK65    
40440 2.309 2624.9 299.4 Homo sapiens adenosine triphosphatase mRNA, complete cds    
44173 2.294 12428.7 1427.3 H.sapiens RbAp48 mRNA encoding retinoblastoma binding protein    
44255 2.292 3820.1 439.0 Human MRL3 mRNA for ribosomal protein L3 homologue ( MRL3 = mammalian ribosome L3 )    
343465 2.289 8114.8 933.8 GAP JUNCTION ALPHA-4    
41511 2.283 10701.5 1234.7 Human translational initiation factor 2 beta subunit (elF-2-beta) mRNA, complete cds    
51740 0.436 10917.4 6596.8 Human mRNA for mitochondrial 3-ketoacyl-CoA thiolase beta-subunit of trifunctional protein, comple  
33045 0.435 4609.5 2790.7 Human neuropeptide Y peptide YY receptor mRNA, complete cds"  
31238 0.432 10388.8 6339.3 Homo sapiens brain thiol-specific antioxidant protein mRNA, complete    
346396 0.430 1663.8 1018.6 R-RAS  
323555 0.426 1612.5 998.0 fyn = syn = slk    
470602 0.426 1399.3 866.0 STEROID HOR RECEPTOR ERR1    
36202 0.422 8191.4 5116.4 Human ribosomal protein L29 (humrpl29) mRNA, complete cds    
22012 0.421 1804.9 1129.5 Human ADP-ribosylation factor (ARF3) mRNA, complete cds    
50503 0.414 1297.7 825.1 Human leukocyte adhesion protein (LFA-1/Mac-1/p150,95 family) beta subunit mRNA    
427857 0.414 1993.4 1268.9 Cyclin A  
43960 0.409 4187.9 2695.7 Human RSU-1/RSP-1 mRNA, complete cds    
487965 0.406 1915.5 1244.1 HHR6A = rad6 homologue    
26585 0.403 1353.6 885.4 Human ORF mRNA, complete cds    
41208 0.402 1449.2 948.8 Homo sapiens (clone KT2) bone morphogenetic protein-1 (BMP-1) mRNA and alternatively spliced mammal  
345600 0.402 1794.3 1176.7 stk2 = serine / threonine kinase 2    
43719 0.399 9420.9 6223.6 Human protein phosphatase 2A-alpha catalytic subunit mRNA, complete cds    
62186 0.399 2418.2 1597.0 BTF3a  
33176 0.396 4745.1 3155.1 Human mRNA for cathepsin H (E.C.3.4.22.16.)    
37231 0.396 1466.2 975.2 Homo sapiens connexin 37 (GJA4) mRNA, complete cds    
323776 0.396 2053.5 1365.0 bFGF  = basic FGF = FGF-2    
375724 0.395 39155.3 26126.0 CAMP-dependent transcription factor ATF-4 (CREB2)    
47384 0.393 2835.4 1902.6 Human  methylenetetrahydrofolate dehydrogenase- methenyltetrahydrofolate cyclohydrolase-formyltetra  
28595 0.392 3558.1 2389.0 Human leukotriene A-4 hydrolase mRNA, complete cds"  
343166 0.390 2121.0 1433.6 PSSALRE = cdk5    
49777 0.388 5696.8 3868.3 Human ornithine decarboxylase antizyme (Oaz) mRNA, complete cds    
33008 0.380 1525.4 1058.6 Human aldose reductase mRNA, complete cds    
45851 0.380 7642.0 5295.4 Human collagen type XVIII alpha 1 (COL18A1) mRNA, partial cds    
26922 0.377 1858.7 1298.6 Homo sapiens (clone 13a) deoxyhypusine synthase mRNA, complete cds    
27794 0.376 10536.5 7378.0 H.sapiens hnRNP-E2 mRNA    
22589 0.374 1337.0 940.9 Human mRNA (KIAA0085) for ORF (novel protein), partial cds    
40205 0.372 7059.7 5000.0 Human cathepsin B proteinase mRNA, complete cds    
364278 0.372 1212.4 858.2 c-maf = NRL  
154420 0.370 1056.4 752.3 PDGF receptor beta-like    
471889 0.370 1253.4 893.2 COUP TRANSCRIPTION FACTOR    
44311 0.368 2581.3 1849.3 H.sapiens MGF gene exons 1&2    
45840 0.364 2084.7 1506.5 Human pre-mRNA splicing factor SRp75 mRNA, complete cds    
429142 0.357 1229.7 908.3 PKA-C alpha = protein kinase A catalytic subunit, alpha isoform    
44495 0.354 1653.4 1231.3 H.sapiens HSJ1 mRNA    
32319 0.353 1151.9 858.3 Human mRNA for protein gene product (PGP) 9.5    
39796 0.351 4039.1 3031.9 Human hydroxymethylglutaryl-CoA lyase mRNA, complete cds    
366509 0.350 3018.7 2274.9 skeletal alpha-actin    
26789 0.347 3335.9 2530.2 Human laminin B2 chain mRNA, complete cds    
262691 0.347 1139.9 865.2 GLUCOCORTICOID RECEPTOR, B    
22379 0.345 6099.7 4659.9 Human lymphocytic antigen CD59/MEM43 mRNA, complete cds    
486233 0.343 2712.8 2082.6 RAB-7  
143751 0.339 1539.3 1195.4 LSP1 = lymphocyte-specific protein 1    
25485 0.337 1017.5 794.8 Homo sapiens neuroendocrine-specific protein A (NSP) mRNA, complete cds    
44193 0.336 4086.6 3202.9 Human vinculin mRNA, complete cds    
310428 0.334 1004.0 791.3 PISSLRE = novel cdk    
37380 0.330 1247.0 994.9 Human proalpha 1 (I) chain of type I procollagen mRNA (partial)    
53184 0.330 1001.6 800.1 Human transcobalamin II (TCII) mRNA, complete cds    
280768 0.328 3976.2 3194.8 Tumor Associated Antigen L6    
23692 0.321 1229.4 1007.9 Human murine sarcoma 3611 viral (v-raf) oncogene homolog 1 (ARAF1) gene, exons 1-16    
40764 0.321 2258.7 1855.1 Human AD amyloid mRNA, complete cds    
47306 0.320 2320.8 1911.6 Human mRNA for protein kinase C delta-type    
306013 0.318 4646.7 3845.4 CD20 p35 subunit = B1    
50999 0.313 2968.7 2497.7 Human aldehyde dehydrogenase 1 mRNA    
36681 0.311 7886.4 6685.6 H.sapiens mRNA for IgM heavy chain constant region (mAb61)    
26593 0.308 1403.4 1201.0 Human complement C1r mRNA, complete cds    
42352 0.308 7045.8 6032.9 Human ADP/ATP translocase mRNA, 3' end, clone pHAT8    
44722 0.303 1799.7 1563.9 H.sapiens mRNA for transcript associated with monocyte to macrophage differentiation    
26871 0.302 1139.9 995.0 Fibroblast growth factor receptor 2    
34005 0.301 1809.4 1581.2 Interferon gamma receptor beta chain    
49751 0.299 1699.1 1497.5 H.sapiens mRNA for alpha 7B integrin    
50363 0.293 2595.8 2336.4 Human nonerythroid alpha-spectrin (SPTAN1) mRNA, complete cds    
53128 0.292 2463.5 2224.2 Human casein kinase I delta mRNA, complete cds    
259291 0.291 3832.6 3474.6 INTEGRIN BETA-5    
34005 0.286 2310.8 2127.8 Human clone pSK1 interferon gamma receptor accessory factor-1 (AF-1)    
327396 0.285 2568.4 2371.4 PITSLRE alpha 1    
485690 0.283 7235.5 6732.1 MYOSIN HEAVY CHAIN    
52629 0.282 1151.3 1075.8 Homo sapiens cam kinase I mRNA, complete cds    
50032 0.279 2732.8 2583.9 Human interferon-gamma receptor mRNA, complete cds    
418138 0.279 2671.2 2521.1 shp = sh-ptp1 = ptp1c = hcp    
486716 0.273 3003.2 2898.9 erk1 = extracellular signal-regulated kinase 1    
52652 0.272 1284.3 1243.6 Human factor H homologue mRNA, complete cds    
36904 0.270 4020.3 3914.7 Human mRNA for CIRP    
23731 0.268 1774.3 1745.3 Human peptidylglycine alpha-amidating monooxygenase mRNA, complete cds    
39827 0.263 6659.1 6671.9 Human 136-kDa double-stranded RNA binding protein p136 (K88dsRBP) mRNA, complete cds    
26052 0.261 3060.6 3084.7 Human glutathione S-transferase mRNA, complete cds    
114116 0.261 1919.8 1939.1 Syndecan-2 = heparin sulfate proteoglycan core protein    
51461 0.255 11140.3 11497.5 H.sapiens hH3.3B gene for histone H3.3    
299539 0.253 1606.4 1669.7 FHF-1 = fibroblast growth factor homologous factor 1    
45376 0.252 1750.8 1830.0 Human mRNA for mitochondrial 3-oxoacyl-CoA thiolase, complete cds    
52162 0.247 1236.4 1317.9 Elongin B = SIII p18 subunit    
41094 0.245 967.7 1041.0 Human tie mRNA for putative receptor tyrosine kinase    
39169 0.243 2965.1 3209.4 Human 26-kDa cell surface protein TAPA-1 mRNA, complete cds    
359793 0.241 7110.4 7755.2 IGF  II  
486560 0.229 2541.3 2929.2 T-CELL SURFACE GLYC    
256323 0.228 7728.9 8947.1 SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3    
38983 0.227 2396.3 2775.6 Human placental FXIIIa mRNA, complete cds    
22589 0.223 1206.9 1427.8 Human retinoic acid-inducible E3 protein mRNA, complete cds    
44302 0.223 3239.7 3828.0 Human heat shock protein (hsp 70) gene, complete cds    
40765 0.216 6433.0 7841.0 human hla-dr antigen alpha-chain mrna & ivs fragments    
238577 0.215 828.7 1014.3 MHC Class II = DP beta    
310406 0.213 1417.8 1756.3 IL-6  
24652 0.211 1297.0 1618.0 Human CD34 mRNA, complete cds    
77577 0.205 887.8 1143.4 fra-2  
486844 0.205 1065.5 1365.7 GAP JUNCTION ALPHA-1    
50555 0.201 20291.1 26586.7 H.sapiens mRNA for ribosomal protein L3    
154472 0.200 1484.4 1958.5 Fibroblast growth factor receptor 1    
24642 0.197 2332.5 3117.8 Human phosphodiesterase I alpha mRNA    
359769 0.191 10000.5 13787.0 mss4  
36191 0.190 2916.0 4036.1 Human mRNA for fibronectin (FN precursor)    
32409 0.186 858.4 1216.1 Human mRNA (HA1756) for ORF, complete cds    
108837 0.180 882.3 1288.6 MCAF  
34327 0.172 30450.2 46570.6 Human cellular oncogene c-fos (complete sequence)    
49725 0.170 1066.2 1648.1 H.sapiens mRNA for neuropeptide Y-like receptor    
49967 0.170 1571.9 2438.1 Human intercellular adhesion molecule 2 (ICAM-2) gene    
27681 0.169 1221.9 1908.1 Human smooth muscle cell calponin mRNA, complete cds    
47648 0.169 2469.7 3858.4 Human endoglin mRNA, 3' end    
357807 0.165 1063.3 1696.0 Cyclin E  
512276 0.164 874.2 1403.7 vimentin  
357909 0.160 1462.7 2406.6 Receptor PTP mu = hR-PTPu    
51940 0.159 22832.5 37873.9 Human beta-2 microglobulin gene mRNA, 3' end    
144944 0.158 643.1 1068.8 LESTR = 7 transmembrane receptor    
471631 0.157 597.9 1002.6 Human mRNA for transcription factor AREB6, complete cds    
37796 0.153 1206.7 2074.4 Human DNA for osteopontin, complete cds    
259241 0.153 918.2 1576.5 HLA II M alpha    
43711 0.152 7934.8 13753.1 Human steroid 5-alpha-reductase mRNA, complete cds    
36950 0.146 1397.1 2523.3 Human liver-type 1-phosphofructokinase (PFKL) mRNA, complete cds    
145932 0.146 631.1 1136.6 Fc epsilon receptor gamma chain    
484993 0.144 1420.0 2602.4 CD81 ANTIGEN    
30012 0.143 1121.9 2072.4 H.sapiens mRNA for high endothelial venule    
132420 0.142 723.7 1346.7 ets-2  
22445 0.140 1994.6 3765.1 Human cytochrome b561 gene    
268652 0.134